ParkinsonCanadaV1, Main, Exploration, bibRecord, 002670

Isolation, expression, and characterization of the human ZCRB1 gene mapped to 12q12

Identifieur interne : 002670 ( Main/Exploration ); précédent : 002669; suivant : 002671

Isolation, expression, and characterization of the human ZCRB1 gene mapped to 12q12

Auteurs : HAORAN WANG [Canada, République populaire de Chine] ; Mary X. Gao [Canada, Japon] ; LINDA LI [République populaire de Chine] ; BIN WANG [République populaire de Chine] ; Naohiro Hori [Japon] ; Kenzo Sato [Japon]

Source :

Genomics : (San Diego, Calif.) [ 0888-7543 ] ; 2007.

RBID : Pascal:07-0085183

Descripteurs français

Pascal (Inist)
- Isolement, Expression génique, Caractérisation, Homme, Gène, Dépendance, Température, Stress, Génomique, Choc.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Characterization, Dependence, Gene, Gene expression, Genomics, Human, Isolation, Shock, Stress, Temperature.

Abstract

While isolating morphine-dependence-related genes with differential display, we cloned a novel human gene, zinc finger CCHC-type and RNA-binding motif 1 (ZCRB1, alias MADP-1), encoding a nuclear protein (217 residues). The ZCRBI gene consists of eight exons and seven introns. It is mapped to 12ql2, which is within a locus reported for Parkinson disease (M. Funayama et al., Ann. Neurol. 51 (2002) 296-301). The 5'-flanking region contains an enhancer core motif and binding sites for AP-1, AP-2, and LF-A1. ZCRB1 is characterized by an RNA-binding motif and a CCHC zinc finger motif. The latter overlaps the C..C...GH....C core nucleocapsid motif. ZCRB1 is conserved from zebrafish to human and shares homology with cold-inducible RNA-binding protein. Transfection assay showed that ZCRB1 is located in the nucleoplasm, but outside the nucleolus. ZCRB1 gene expression was stimulated by morphine, inhibited by 30-36°C, and up-regulated by 39°C incubation in SH-SY5Y neural cells. Zcrbl gene expression is highest in the heart and testes, lower in the cerebellum, and lowest in the liver in mice. ZCRB1 mRNA expression is specifically elevated in hepatocarcinoma HepG2 cells. These data provide new clues for further understanding of morphine dependence, heat shock, and hepatocarcinoma.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000775
to stream PascalFrancis, to step Curation: 000545
to stream PascalFrancis, to step Checkpoint: 000638
to stream Main, to step Merge: 002928
to stream Main, to step Curation: 002670

Le document en format XML

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<front><div type="abstract" xml:lang="en">While isolating morphine-dependence-related genes with differential display, we cloned a novel human gene, zinc finger CCHC-type and RNA-binding motif 1 (ZCRB1, alias MADP-1), encoding a nuclear protein (217 residues). The ZCRBI gene consists of eight exons and seven introns. It is mapped to 12ql2, which is within a locus reported for Parkinson disease (M. Funayama et al., Ann. Neurol. 51 (2002) 296-301). The 5'-flanking region contains an enhancer core motif and binding sites for AP-1, AP-2, and LF-A1. ZCRB1 is characterized by an RNA-binding motif and a CCHC zinc finger motif. The latter overlaps the C..C...GH....C core nucleocapsid motif. ZCRB1 is conserved from zebrafish to human and shares homology with cold-inducible RNA-binding protein. Transfection assay showed that ZCRB1 is located in the nucleoplasm, but outside the nucleolus. ZCRB1 gene expression was stimulated by morphine, inhibited by 30-36°C, and up-regulated by 39°C incubation in SH-SY5Y neural cells. Zcrbl gene expression is highest in the heart and testes, lower in the cerebellum, and lowest in the liver in mice. ZCRB1 mRNA expression is specifically elevated in hepatocarcinoma HepG2 cells. These data provide new clues for further understanding of morphine dependence, heat shock, and hepatocarcinoma.</div>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Isolation, expression, and characterization of the human ZCRB1 gene mapped to 12q12

Isolation, expression, and characterization of the human ZCRB1 gene mapped to 12q12

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri